Modified Proteases for Peptide Synthesis in Organic Media

  title={Modified Proteases for Peptide Synthesis in Organic Media},
  author={I. Yu. Filippova and Elena N Lysogorskaya},
  journal={Russian Journal of Bioorganic Chemistry},
We showed that modified proteases could catalyze synthesis of a wide variety of peptides of various lengths and structures both in solution and on solid phase in organic solvents. The following modified proteases were studied as catalysts for enzymatic peptide synthesis in polar organic solvents (acetonitrile, dimethylformamide, and ethanol): pepsin sorbed… CONTINUE READING