Modified M2 proteins produce heterotypic immunity against influenza A virus.

@article{Frace1999ModifiedMP,
  title={Modified M2 proteins produce heterotypic immunity against influenza A virus.},
  author={A. Michael Frace and Alexander I. Klimov and Thomas Rowe and Ron Black and Jacqueline M. Katz},
  journal={Vaccine},
  year={1999},
  volume={17 18},
  pages={2237-44}
}
Vaccination with the influenza A transmembrane protein M2 provides enhanced viral clearance and recovery from influenza A virus infection in mice. However, the high degree of hydrophobicity of the protein limits its purification for vaccine purposes. We have attempted to alter the structure of the M2 protein to allow high level recombinant expression in Escherichia coli, to reduce its hydrophobicity and improve protein solubility, thus improving its properties as a vaccine subunit candidate… CONTINUE READING

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