Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins

@inproceedings{Florens2016ModifiedLA,
  title={Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins},
  author={Nans Florens and Catherine Calzada and Egor Lyasko and Laurent Juillard and Christophe O. Soulage},
  booktitle={Toxins},
  year={2016}
}
Chronic kidney disease (CKD) is associated with an enhanced oxidative stress and deep modifications in lipid and lipoprotein metabolism. First, many oxidized lipids accumulate in CKD and were shown to exert toxic effects on cells and tissues. These lipids are known to interfere with many cell functions and to be pro-apoptotic and pro-inflammatory, especially in the cardiovascular system. Some, like F2-isoprostanes, are directly correlated with CKD progression. Their accumulation, added to their… CONTINUE READING
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