Modified LDLs are internalized by macrophages in part via macropinocytosis.

  title={Modified LDLs are internalized by macrophages in part via macropinocytosis.},
  author={Nancy L. Jones and Mark C. Willingham},
  journal={The Anatomical record},
  volume={255 1},
Macrophage foam cell formation in vitro requires uptake of modified low density lipoproteins (LDL) such as acetylated LDL (AcLDL) and moderately oxidized LDL (OxLDL). Macrophages incubated with AcLDL and OxLDL, but not LDL, showed increased membrane ruffling as seen with time-lapse phase contrast video light microscopy. Modified LDLs stimulated circular membrane ruffles between 2 and 10 min after incubation. These membrane ruffles were readsorbed into the plasma membrane between 5 and 15 min… CONTINUE READING
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