Modified K-channel gating by exhaustion and the block by internally applied TEA+ and 4-aminopyridine in muscle

@article{Fink1978ModifiedKG,
  title={Modified K-channel gating by exhaustion and the block by internally applied TEA+ and 4-aminopyridine in muscle},
  author={Renate Fink and Erich Wettwer},
  journal={Pfl{\"u}gers Archiv},
  year={1978},
  volume={374},
  pages={289-292}
}
Voltage clamp experiments on frog sartorius muscle fibres suggest that the large increase in resting potassium conductance during metabolic exhaustion is due to a change in the gating of activated potassium channels to a permanently open state. gK in exhausted fibres is less sensitive to externally applied blockers as Zn2+ and 4-aminopyridine (4-AP) while TEA+, Rb+ and Ba2+ act similarly, both in normal and exhausted fibres. In addition, injection experiments provide evidence that TEA+ and 4-AP… CONTINUE READING

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An evaluation of the membrane constants and the potassium conductance in metabolically exhausted muscle fibres

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