Modifications of the iron-neuromelanin system in Parkinson's disease.

  title={Modifications of the iron-neuromelanin system in Parkinson's disease.},
  author={Mauro Fasano and Bruno Bergamasco and Leonardo Lopiano},
  journal={Journal of neurochemistry},
  volume={96 4},
Parkinson's disease is a common neurodegenerative disorder with a mainly sporadic aetiology, although a number of monogenic familiar forms are known. Most of the motor symptoms are due to selective depletion of dopaminergic, neuromelanin-containing neurones of the substantia nigra pars compacta. Neuromelanin is the dark insoluble macromolecule that confers the black (substantia nigra) or grey (locus coeruleus) colour to monoaminergic basal ganglia. In particular, nigral neurones are pigmented… CONTINUE READING