Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide.

@article{Vandevoorde2003ModificationsOT,
  title={Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide.},
  author={S{\'e}verine Vandevoorde and K O Jonsson and Christopher J Fowler and Didier Lambert},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 8},
  pages={1440-8}
}
The endogenous fatty acid amide anandamide (AEA) has, as a result of its actions on cannabinoid and vanilloid receptors, a number of important pharmacological properties including effects on nociception, memory processes, spasticity, and cell proliferation. Inhibition of the metabolism of AEA, catalyzed by fatty acid amide hydrolase (FAAH), potentiates the actions of AEA in vivo and therefore may be a useful target for drug development. In the present study, we have investigated whether… CONTINUE READING

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Endocannabinoids control spasticity in a multiple sclerosis model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2001

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