Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities.

@article{Nielsen1998ModificationsOT,
  title={Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities.},
  author={Simon Feldbaek Nielsen and Arsalan Kharazmi and S\oren Br\ogger Christensen},
  journal={Bioorganic & medicinal chemistry},
  year={1998},
  volume={6 7},
  pages={937-45}
}
Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore. 

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