Modifications of the 5' cap of mRNAs during Xenopus oocyte maturation: independence from changes in poly(A) length and impact on translation.

@article{GillianDaniel1998ModificationsOT,
  title={Modifications of the 5' cap of mRNAs during Xenopus oocyte maturation: independence from changes in poly(A) length and impact on translation.},
  author={Donald L Gillian-Daniel and Nicola K Gray and Jan {\AA}str{\"o}m and Allen Barkoff and M. J. Wickens},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 10},
  pages={
          6152-63
        }
}
The translation of specific maternal mRNAs is regulated during early development. For some mRNAs, an increase in translational activity is correlated with cytoplasmic extension of their poly(A) tails; for others, translational inactivation is correlated with removal of their poly(A) tails. Recent results in several systems suggest that events at the 3' end of the mRNA can affect the state of the 5' cap structure, m7G(5')ppp(5')G. We focus here on the potential role of cap modifications on… CONTINUE READING
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