Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation.

@article{Owen1990ModificationsOP,
  title={Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation.},
  author={Thomas A. Owen and Jan Holthuis and E R Markose and Andre J van Wijnen and Scot A. Wolfe and Sidney R. Grimes and Jane B Lian and Gary S Stein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 13},
  pages={5129-33}
}
A temporal sequence of interrelated cellular, biochemical, and molecular events which occurs during the progressive expression of the differentiated osteoblast phenotype in primary cultures of fetal rat calvarial cells results in the development of a bone-tissue-like organization. This ordered developmental sequence encompasses three periods: proliferation, matrix maturation, and mineralization. Initially, the cells actively proliferate and synthesize type I collagen. This is followed by a… CONTINUE READING
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