Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection.

@article{Caini2007ModificationsOP,
  title={Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection.},
  author={Patrizio Caini and Cristina Tosti Guerra and Carlo Giannini and Francesca Giannelli and L Gragnani and Antonio Petrarca and Vera Solazzo and Monica Monti and Giacomo Laffi and Anna Linda Zignego},
  journal={Journal of viral hepatitis},
  year={2007},
  volume={14 1},
  pages={22-8}
}
Hepatitis C virus (HCV) chronically infects about 200 million individuals worldwide and leads to severe liver and lymphatic diseases. HCV circulates in the serum, associated with apoB-containing lipoproteins. Platelet-activating factor (PAF), a pro-inflammatory mediator, is mainly modulated by plasma PAF-acetylhydrolase (pPAF-AH), associated with ApoB100-containing low-density lipoproteins (LDL). The aim of the study was to evaluate the potential effects of chronic HCV infection on the PAF/pPAF… CONTINUE READING