Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells.

@article{Vergelli1997ModificationsOP,
  title={Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells.},
  author={Marco Vergelli and Bernhard Hemmer and Matthias Kalbus and Anne B. Vogt and Nicholas Ling and Paul A. Conlon and John E. Coligan and Henry F. McFarland and Roland Martin},
  journal={Journal of immunology},
  year={1997},
  volume={158 8},
  pages={
          3746-52
        }
}
In this report, we demonstrate for autoreactive T cell clones that single amino acid modifications of the antigenic ligand can result in not only abrogated, decreased, or unmodified, but also increased, T cell responsiveness (superagonist ligands). We further studied the effects of combinations of multiple substitutions with different effects in single peptides. Experiments with peptides carrying multiple amino acid exchanges revealed that the final outcome of TCR ligation by a given ligand is… CONTINUE READING
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