Modifications of microsomal and nuclear fractions by butylated hydroxyanisole and its effect on benzo(a)pyrene metabolites binding to macromolecules.

Abstract

The effect of butylated hydroxyanisole (BHA) administration on the hepatic components of the monooxygenase system and lipid peroxidation in microsomal and nuclear fractions was investigated in male Swiss mice. Addition of BHA to the diet for 8 days increased significantly the content of cytochrome P-450 (by 50%) and two times the specific activities of NADH… (More)

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