Modifications of local cerebral glucose utilization in thalamic structures following injection of a dopaminergic agonist in the nucleus accumbens--involvement in antiepileptic effects?

@article{Riban2004ModificationsOL,
  title={Modifications of local cerebral glucose utilization in thalamic structures following injection of a dopaminergic agonist in the nucleus accumbens--involvement in antiepileptic effects?},
  author={V{\'e}ronique Riban and Anne Pereira de Vasconcelos and Bich-Thuy Pham-L{\^e} and Arielle Ferrandon and C. Marescaux and Astrid Nehlig and A. Depaulis},
  journal={Experimental neurology},
  year={2004},
  volume={188 2},
  pages={452-60}
}
Dopaminergic transmission in the nucleus accumbens (NAcc) is implicated in different aspects of reward and motivational mechanisms. More recently, it has been suggested that this nucleus could also be involved in the modulation of generalized epileptic seizures. In particular, microinjection of dopaminergic agonists in the NAcc suppresses the occurrence of epileptic seizures in a model of absence seizures, the GAERS (generalized absence epileptic rats from Strasbourg). The aim of this study was… CONTINUE READING