Modifications of hepatic microsomal 9-oxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine.


1. The hepatic microsomal 9-hydroxylation of N-2-fluorenylacetamide (2-FAA) is greater in the presence of male, or absence of female, hormones. Thus, 9-hydroxy-2-FAA was the major microsomal metabolite of male rats, which formed 6-fold greater amounts than did female rats. One week after gonadectomy, the amount of 9-hydroxy-2-FAA formed by male rats was… (More)


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