Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants.

@article{Scheible2001ModificationsOC,
  title={Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants.},
  author={Wolf R Scheible and Ravit Eshed and Todd Richmond and Deborah P. Delmer and Chris Somerville},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 18},
  pages={10079-84}
}
In many higher plants, cellulose synthesis is inhibited by isoxaben and thiazolidinone herbicides such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl) phenyl-4-thiazolidinone. Semidominant mutations at the IXR1 and IXR2 loci of Arabidopsis confer isoxaben and thiazolidinone resistance. Isolation of the IXR1 gene by map-based cloning revealed that it encodes the AtCESA3 isoform of cellulose synthase. The two known mutant alleles contain point mutations that replace glycine 998 with aspartic… CONTINUE READING
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