Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

@inproceedings{Krezymon2013ModificationsOH,
  title={Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease},
  author={Alice Krezymon and Kevin Richetin and H{\'e}l{\`e}ne Halley and Laurent Roybon and Jean-Michel Lassalle and Bernard Franc{\'e}s and Laure Verret and Claire Rampon},
  booktitle={PloS one},
  year={2013}
}
At advanced stages of Alzheimer's disease, cognitive dysfunction is accompanied by severe alterations of hippocampal circuits that may largely underlie memory impairments. However, it is likely that anatomical remodeling in the hippocampus may start long before any cognitive alteration is detected. Using the well-described Tg2576 mouse model of Alzheimer's disease that develops progressive age-dependent amyloidosis and cognitive deficits, we examined whether specific stages of the disease were… CONTINUE READING
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