Modifications of A-current kinetics in mammalian central neurones induced by extracellular zinc.

@article{Bardoni1994ModificationsOA,
  title={Modifications of A-current kinetics in mammalian central neurones induced by extracellular zinc.},
  author={Rita Bardoni and Ottorino Belluzzi},
  journal={The Journal of physiology},
  year={1994},
  volume={479 ( Pt 3)},
  pages={389-400}
}
1. Whole-cell voltage clamp recordings were used to study the action of the transition ion zinc on the A-current kinetics in granule cells from rat cerebellar slices. 2. The effects of zinc have been tested in the concentration range from 1 microM to 1 mM, and fully characterized on all kinetic parameters at 100 and 300 microM. All the effects observed were rapid, concentration dependent and fully reversible. 3. Steady-state inactivation curves are strongly shifted towards depolarized… CONTINUE READING

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