Modifications in Retinal Mitochondrial Respiration Precede Type 2 Diabetes and Protracted Microvascular Retinopathy.

@article{Han2017ModificationsIR,
  title={Modifications in Retinal Mitochondrial Respiration Precede Type 2 Diabetes and Protracted Microvascular Retinopathy.},
  author={Woo Hyun Han and Jonathan Gotzmann and Sharee L Kuny and Hui Huang and Catherine B Chan and H{\'e}l{\`e}ne Lemieux and Yves Sauv{\'e}},
  journal={Investigative ophthalmology & visual science},
  year={2017},
  volume={58 10},
  pages={3826-3839}
}
Purpose To characterize retinal mitochondrial respiration associated with type 2 diabetes (T2D) progression in a cone-rich diurnal rodent, the Nile rat (genus Arvicanthis, species niloticus). Methods Nile rats were fed a standard rodent diet that resulted in rising glucose levels from 6 months. Age-matched control animals were fed a high-fiber diet that prevented diabetes up to 18 months. The functional status of specific retinal mitochondrial components and mitochondrial outer membrane… CONTINUE READING
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Dysfucntional fatty acid oxidation and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rat

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