Modification of tight junction function by protein kinase C isoforms.

@article{Clarke2000ModificationOT,
  title={Modification of tight junction function by protein kinase C isoforms.},
  author={Hector Clarke and Cristina Marano and Alejandro Peralta Soler and James M Mullin},
  journal={Advanced drug delivery reviews},
  year={2000},
  volume={41 3},
  pages={283-301}
}
The regulation of tight junction permeability by a variety of signal transduction pathways is summarized. An emphasis is placed on regulation of paracellular permeability by the protein kinase C family of isoforms, which involves the reporting of a large number of studies using the phorbol ester family of protein kinase C activators. The ability of protein kinase C activation to open epithelial barriers to a very wide range of solutes is emphasized, but then countered with discussion of the… CONTINUE READING

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