Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxes.

@article{Armengod2014ModificationOT,
  title={Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxes.},
  author={M. Eugenia Armengod and Salvador Meseguer and Magda Villarroya and Silvia Regina Tozato Prado and Isma{\"i}l Moukadiri and Rafael Ruiz-Partida and Mar{\'i}a Jos{\'e} Garz{\'o}n and Carmen Navarro-Gonz{\'a}lez and Ana Mart{\'i}nez-Zamora},
  journal={RNA biology},
  year={2014},
  volume={11 12},
  pages={1495-507}
}
Posttranscriptional modification of the uridine located at the wobble position (U34) of tRNAs is crucial for optimization of translation. Defects in the U34 modification of mitochondrial-tRNAs are associated with a group of rare diseases collectively characterized by the impairment of the oxidative phosphorylation system. Retrograde signaling pathways from… CONTINUE READING

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