Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71.

@article{Drenichev2016ModificationOT,
  title={Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71.},
  author={Mikhail S Drenichev and Vladimir E Oslovsky and Liang Sun and Aloys Tijsma and Nikolay N. Kurochkin and Vitali I Tararov and Alexander O Chizhov and Johan Neyts and C Pannecouque and Pieter Leyssen and Sergey N Mikhailov},
  journal={European journal of medicinal chemistry},
  year={2016},
  volume={111},
  pages={84-94}
}
Very recently, we demonstrated that N(6)-isopentenyladenosine, a cytokinin nucleoside, exerts a potent and selective antiviral effect on the replication of human enterovirus 71. The present study is devoted to the structure optimization of another natural compound: N(6)-benzyladenosine. We mainly focused on the exploration of the size and nature of the linker between the adenine and the phenyl ring, as well as on the necessity of the D-ribose residue. More than 30 analogues of N(6… CONTINUE READING

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