Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.

@article{Theodoratou2008ModificationOT,
  title={Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.},
  author={Evropi Theodoratou and Susan M Farrington and Albert Tenesa and Geraldine McNeill and Roseanne Cetnarskyj and Rebecca A. Barnetson and Mary E M Porteous and Malcolm G Dunlop and Harry Campbell},
  journal={International journal of cancer},
  year={2008},
  volume={123 9},
  pages={2170-9}
}
Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control study, we investigated (i) main associations between CRC, vitamin D and calcium dietary intake and 4 VDR single nucleotide polymorphisms (rs10735810, rs1544410, rs11568820, rs7975232… CONTINUE READING
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