Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates.

Abstract

The modification and concomitant inactivation of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity analogs of peptide substrates potentially capable of undergoing disulfide interchange with enzyme-bound sulfhydryl groups have been used to probe the active site associated with peptide binding. The regeneration of catalytic… (More)

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@article{Bramson1982ModificationOT, title={Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates.}, author={Heidi Bramson and N. Thomas and Ross L. Matsueda and Nick Nelson and S. S. Taylor and Elsi Kaiser}, journal={The Journal of biological chemistry}, year={1982}, volume={257 18}, pages={10575-81} }