Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection

@inproceedings{Cole2012ModificationOT,
  title={Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection},
  author={David K Cole and Kathleen Gallagher and Brigitte Lemercier and Christopher J. Holland and Sayed Junaid and James P. Hindley and Katherine K. Wynn and Emma Gostick and Andrew K. Sewell and Awen Gallimore and Kristin Ladell and David A. Price and M L Gougeon and Andrew J. Godkin},
  booktitle={Nature communications},
  year={2012}
}
Human CD4(+) αβ T cells are activated via T-cell receptor recognition of peptide epitopes presented by major histocompatibility complex (MHC) class II (MHC-II). The open ends of the MHC-II binding groove allow peptide epitopes to extend beyond a central nonamer core region at both the amino- and carboxy-terminus. We have previously found that these non-bound C-terminal residues can alter T cell activation in an MHC allele-transcending fashion, although the mechanism for this effect remained… CONTINUE READING
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