Modification of the active site of Mycobacterium tuberculosis KatG after disruption of the Met-Tyr-Trp cross-linked adduct.

Abstract

Mycobacterium tuberculosis catalase-peroxidase (Mtb KatG) is a bifunctional enzyme that possesses both catalase and peroxidase activities and is responsible for the activation of the antituberculosis drug isoniazid. Mtb KatG contains an unusual adduct in its distal heme-pocket that consists of the covalently linked Trp107, Tyr229, and Met255. The KatG(Y229F… (More)

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@article{Kapetanaki2007ModificationOT, title={Modification of the active site of Mycobacterium tuberculosis KatG after disruption of the Met-Tyr-Trp cross-linked adduct.}, author={Sofia M Kapetanaki and Xiangbo Zhao and Shengwei Yu and Richard S. Magliozzo and Johannes P M Schelvis}, journal={Journal of inorganic biochemistry}, year={2007}, volume={101 3}, pages={422-33} }