Modification of simian virus 40 large tumor antigen by glycosylation.

  title={Modification of simian virus 40 large tumor antigen by glycosylation.},
  author={Donald L. Jarvis and Janet S Butel},
  volume={141 2},
The SV40-encoded transforming protein, large tumor antigen (T-ag), is multifunctional. Chemical modifications of the T-ag polypeptide may be important for its multifunctional capacity. T-ag is additionally modified by glycosylation. T-ag was metabolically labeled in SV40-infected cells with tritiated galactose or glucosamine, but not with mannose or fucose. The identity of glycosylated T-ag was established by immunoprecipitation with a variety of T-ag-specific antisera, including monoclonal… CONTINUE READING