Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiation.


A simple chemical modification method using diazonium coupling chemistry was developed to tailor the structure and hydrophilicity of silk fibroin protein. The extent of modification using several aniline derivatives was characterized using UV-vis and 1H NMR spectroscopies, and the resulting protein structure was analyzed with ATR-FTIR spectroscopy… (More)
DOI: 10.1016/j.biomaterials.2008.03.039

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