Modification of radiation-induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum: an in vitro study in human blood leukocytes.

@article{Srivastava2014ModificationOR,
  title={Modification of radiation-induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum: an in vitro study in human blood leukocytes.},
  author={Nitya Nand Srivastava and Sandeep Kumar Shukla and M. H. Yashavarddhan and Memita Devi and Rajendra Prashad Tripathi and Manju Lata Gupta},
  journal={Environmental and molecular mutagenesis},
  year={2014},
  volume={55 5},
  pages={436-48}
}
Radiation exposure is a serious threat to biomolecules, particularly DNA, proteins and lipids. Various exogenous substances have been reported to protect these biomolecules. In this study we explored the effect of pre-treatment with G-002M, a mixture of three active derivatives isolated from the rhizomes of Podophyllum hexandrum, on DNA damage response in irradiated human blood leukocytes. Blood was collected from healthy male volunteers, preincubated with G-002M and then irradiated with… CONTINUE READING
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