Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats.

@article{Duarte2007ModificationOP,
  title={Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats.},
  author={Jo{\~a}o M. N. Duarte and Jean P. Oses and Ricardo J Rodrigues and Rodrigo A Cunha},
  journal={Neuroscience},
  year={2007},
  volume={149 2},
  pages={382-91}
}
Diabetic encephalopathy is a recognized complication of untreated diabetes resulting in a progressive cognitive impairment accompanied by modification of hippocampal function. The purinergic system is a promising novel target to control diabetic encephalopathy since it might simultaneously control hippocampal synaptic plasticity and glucose handling. We now tested whether streptozotocin-induced diabetes led to a modification of extracellular ATP homeostasis and density of membrane ATP (P2… CONTINUE READING

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