Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency.

@article{Kim2005ModificationOP,
  title={Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency.},
  author={Tae Woo Kim and Jin-Hyup Lee and Liangmei He and David A K Boyd and Jonathan Hardwick and Chien Fu Hung and T-C Wu},
  journal={Cancer research},
  year={2005},
  volume={65 1},
  pages={309-16}
}
RNA interference using small interfering RNA (siRNA) is an effective means of silencing gene expression in cells. Intradermal administration of nucleic acids via gene gun represents an efficient method for delivering nucleic acids to professional antigen-presenting cells in vivo. In this study, we show that the coadministration of DNA vaccines encoding human papillomavirus type 16 E7 with siRNA targeting key proapoptotic proteins Bak and Bax prolongs the lives of antigen-expressing dendritic… CONTINUE READING