Modification of phospholipid metabolism in human red cells by primaquine. A possible mechanism in drug-induced hemolysis.

@article{Wittels1970ModificationOP,
  title={Modification of phospholipid metabolism in human red cells by primaquine. A possible mechanism in drug-induced hemolysis.},
  author={Benjamin Wittels},
  journal={Biochimica et biophysica acta},
  year={1970},
  volume={210 1},
  pages={
          74-85
        }
}
  • B. Wittels
  • Published 9 June 1970
  • Biology, Chemistry
  • Biochimica et biophysica acta
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EFFECTS OF PRIMAQUINE AND OTHER RELATED COMPOUNDS ON THE RED BLOOD CELL MEMBRANE. I. NA + AND K + PERMEABILITY IN NORMAL HUMAN CELLS
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In vitro prelytic abnormalities in red cell permeability are studied to study the effects of toxic agents on the membranes of the cells as well as their effects on intracellular metabolism.
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Fluorescence spectra of human serum albumin samples indicated that impurities are sometimes present which can be removed by charcoal at neutral pH, and acid-charcoal treatment is a much more rapid method of removing lipid impurities than other methods previously described.
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SUMMARY Thin-layer chromatography of phospholipids and cerebrosides was performed on Silica Gel G plates using a mixture of chloroform-methanol-acetic acid-water as development solvent. Two types of
Synthesen von Cholinphosphatiden, V. Palmitoyl‐propandiol‐(1.3)‐phosphorylcholin (2‐Desoxylysolecithin) und ω.ω′‐Alkandiol‐Analoga
Die Phosphorsaurecholinester 2 einiger Palmitoyl-ω.ω′-alkandiole (1) – im einfachsten Falle von Palmitoyl-propandiol-(1.3) – wurden dargestellt.
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