Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment

@article{Dong2001ModificationON,
  title={Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment},
  author={Jianming Dong and Pierre Blier},
  journal={Psychopharmacology},
  year={2001},
  volume={155},
  pages={52-57}
}
Rationale: Bupropion is widely used in the treatment of depression and as an anti-craving medication for the cessation of tobacco smoking. Because it is a very weak inhibitor of norepinephrine (NE) and dopamine (DA) reuptake, its mechanisms of action remain to be elucidated. Methods: Bupropion was administered subcutaneously via osmotic minipumps over 2 days to determine its effects on the spontaneous firing activity of NE, serotonin (5-HT), and DA neurons in the brain of anaesthetised male… CONTINUE READING
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