Modification of neutron-induced hematopoietic effects by chemical radioprotectors.

  title={Modification of neutron-induced hematopoietic effects by chemical radioprotectors.},
  author={C. Sigdestad and A. M. Connor and C. S. Sims},
  journal={International journal of radiation oncology, biology, physics},
  volume={22 4},
Nine drugs, WR-347, WR-1065, WR-2529, WR-2721, WR-3689, WR-44923, WR-151327, WR-109342, and WR-168643, were assayed for intraperitoneal pharmacological toxicity, hematopoietic lethality, and spleen stem cell survival in C57/Bl mice in conjunction with whole-body fission neutron irradiation. In addition, WR-3689, WR-109342, and WR-168643 were used with per os administration to determine hematopoietic lethality. Drug toxicities after intraperitoneal administration, as determined by LD50's, ranged… Expand
8 Citations
Radioprotection by WR-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation.
WR-151327 has the potential to protect against radiation-induced late normal tissue damage and there were good correlations between leg contracture or skin shrinkage and the other endpoints in both untreated and drug-treated mice. Expand
WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated mice.
WR treatment increases resistance to infection in immunocompromised hosts, and these studies quantify the resistance to bacterial infection in mice treated with WR before sublethal irradiation. Expand
Acute toxicity and radioprotective effects of amifostine (WR-2721) or cystamine in single whole body fission neutrons irradiated rats
University od South Bohemia, Faculty of Health and Social Studies, Department of Radiology and Toxicology, Ceske Budějovice, Czech Republic, Purkyně Military Medical Academy, Department ofExpand
N-acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons
It is shown that pBR322 plasmid DNA is indeed protected against radiolytic strand breakage by both N-Acetylcysteine and captopril, and the oxygen independent protection is consistent with a hydroxyl radical scavenging mechanism. Expand
Photodynamic therapy induced vascular damage: an overview of experimental PDT
The important findings on vascular damage by PDT on mice are reviewed and the combination of PDT with other approaches as well as its effect on cancer photomedicine are reviewed. Expand
Chemical radioprotective substances: The past, the present and the future
Vývoj jaderných zbrani, rostouci potřeba elektricke energie vyraběne atomovými elektrarnami a jejich jaderne havarie, každodenni radioterapie onkologických nemocných a dlouhodobe lety clověka doExpand
A new strategy for chemoselective O-acylation of β-mercapto alcohols via alkylsilyl and stannyl protection
Chemoselective preparation of O-acylated derivatives from bis-protected mercapto alcohols was described. Trialkylsilyl and trialkylstannyl chloride are used to generate an intermediate with O- andExpand
Lipase-catalyzed chemospecific O-acylation of 3-mercapto-1-propanol and 4-mercapto-1-butanol
Abstract The lipase-catalyzed chemospecific O -acylation of 3-mercapto-1-propanol and 4-mercapto-1-butanol by several aliphatic carboxylic acid ethyl esters are described. Similar treatment onExpand


Protection of mice against fission neutron irradiation by WR-2721 or WR-151327.
Small but significant sex differences in radioprotection were found: the DMFs for female mice pretreated with either compound were lower than those for similarly treated male mice; the incidence of mortality 31-100 days postexposure in male mice pretreatment with WR-151327 was greater than forFemale mice. Expand
Toxicity and radiation protective effect of WR-77913 in BALB/c mice.
Because of its low toxicity, adequate bone marrow and gut protection at doses equivalent to one quarter MTD and limited protection of the EMT6 tumor, WR-77913 deserves further investigation to determine its value in multiple drug dose regimens and its capability to protect other normal tissues. Expand
Chemical protection against gastrointestinal radiation injury in mice by WR 2822, WR 2823, or WR 109342 after 4 MeV X ray or fission neutron irradiation.
All three drugs were more toxic and demonstrated less protection in most of these assays than the benchmark radioprotective agent WR 2721, although WR 2822 protected against lethal effects of fission neutrons almost as well asWR 2721. Expand
A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327.
Two thiophosphoroate radiation protectors were assessed for their ability to modify the effects of neutron or gamma irradiation on the gastrointestinal tract and results did not correlate with the intestinal stem cell assays where WR-2721 when compared to WR-151327 showed either similar (DOSAR; fission spectrum neutrons) or somewhat better (60Co and FERMILAB neutrons). Expand
Radioprotection of mouse colony forming units-spleen against heavy-charged particle damage by WR 2721.
The effectiveness of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR 2721) to protect against the heavy-charged particle beams with dose-averaged LET infinity's ranging from 26 to 260Expand
Radiobiolgoical and biochemical studies of thiophosphate radioprotective compounds related to cysteamine.
Both agents protect euoxic marrow-colony forming units (CFUs) in vivo better than cysteamine when the cells are treated with both drug and x-radiation prior to transplantation, and Hypoxic CFUs are protected only slightly. Expand
Estimation of radiation dose-reduction factor for beta-mercaptoethylamine by endogenous spleen colony counts.
As recovery progresses in irradiated mice, colonies of hemopoietic cells become grossly visible on the spleen, the number of colonies being inversely related to radiation dose (1). In studyingExpand
Chemoprotection against three modes of radiation death in the mouse.
  • J. Yuhas, J. Storer
  • Biology, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1969
SummarySeven radioprotective agents have been tested for their ability to protect the mouse against three radiation-induced modes of death. Six of the seven agents offer relatively less protectionExpand
Dose and LET distributions in small-animal sized cylinders for a fission neutron spectrum.
Data indicate that rotation of the animals in the field would result in a "uniform" irradiation condition, despite the fact that unilateral exposure results in maximum to minimum dose ratios greater than 1.30, which according to the ICRU recommendations are classified as "nonuniform". Expand
Chemical radiation protection of the intestinal epithelium by mercaptoethylamine and its thiophosphate derivative.
Abstract Mercaptoethylamine (MEA) was compared to its thlophosphate derivative (MEAP) for protective effects against 4 Mev x-rays and fission neutrons. Intestinal crypt survival, lethality andExpand