Modification of mitogenic response to concanavalin A of lymphocytes from old-aged donors by ion channel blockers.


Mitogenic response of lymphocytes from young and old donors to Concanavalin A in the absence or presence of Na+ channel blocker--saxitoxin--was compared. Effect of Ca++ channel blockers (Verapamil Diltiazem) on mitogenic response of lymphocytes from old subjects was also examined. It was found that the mitogenic response to Concanavalin A of lymphocytes… (More)