Modification of lysyl side chains using citraconic anhydride.

Abstract

INTRODUCTIONReversible masking of ε-amino groups of lysine is a valuable procedure for limiting trypsin hydrolysis of proteins to arginine peptide bonds. Citraconic anhydride is a reversible blocking agent of lysyl side chains. A major advantage of citraconylation is the ease with which the blocking group can be removed under conditions that will not lead… (More)
DOI: 10.1101/pdb.prot4552

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