Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

@article{Steinbrecher1984ModificationOL,
  title={Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.},
  author={Urs P. Steinbrecher and Sampath Parthasarathy and David S. Leake and Joseph L. Witztum and Daniel Steinberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 12},
  pages={3883-7}
}
Low density lipoprotein (LDL) incubated with cultured endothelial cells from rabbit aorta or human umbilical vein is altered in several ways (EC-modified): (i) It is degraded by macrophages much faster than LDL similarly incubated in the absence of cells or incubated with fibroblasts. (ii) Its electrophoretic mobility is increased. (iii) Its density is increased. We report here that antioxidants completely prevent these changes. We also report that these changes do not take place if transition… CONTINUE READING
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