Corpus ID: 38591320

Modification of local anesthetic toxicity by vasoconstrictors.

@article{Taylor1989ModificationOL,
  title={Modification of local anesthetic toxicity by vasoconstrictors.},
  author={S. E. Taylor and R. Dorris},
  journal={Anesthesia progress},
  year={1989},
  volume={36 3},
  pages={
          79-87
        }
}

S. E. Taylor, R. Dorris

Published 1989

Medicine

Anesthesia progress

We studied the effects of epinephrine or levonordefrin on the toxicity (convulsions) and lethality of four local anesthetics in mice. Appropriate doses of procaine, lidocaine, tetracaine or bupivacaine--either alone or in combination with 15 mcg/kg epinephrine or levonordefrin--were injected intravenously into the tail vein of male mice. Dose-response curves were constructed from the data obtained, and the CD50 and LD50 values for each local anesthetic alone and in combination with each of the… CONTINUE READING

View on PubMed

Save to Library

Create Alert

Cite

Launch Research Feed