Corpus ID: 38591320

Modification of local anesthetic toxicity by vasoconstrictors.

  title={Modification of local anesthetic toxicity by vasoconstrictors.},
  author={S. E. Taylor and R. Dorris},
  journal={Anesthesia progress},
  volume={36 3},
  • S. E. Taylor, R. Dorris
  • Published 1989
  • Medicine
  • Anesthesia progress
  • We studied the effects of epinephrine or levonordefrin on the toxicity (convulsions) and lethality of four local anesthetics in mice. Appropriate doses of procaine, lidocaine, tetracaine or bupivacaine--either alone or in combination with 15 mcg/kg epinephrine or levonordefrin--were injected intravenously into the tail vein of male mice. Dose-response curves were constructed from the data obtained, and the CD50 and LD50 values for each local anesthetic alone and in combination with each of the… CONTINUE READING
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