Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity.

@article{Ley2001ModificationOL,
  title={Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity.},
  author={Peter van der Ley and Liana Juliana Josephine Steeghs and Hendrik Jan Hamstra and Jan Bart Ten Hove and B Zomer and Loek van Alphen},
  journal={Infection and immunity},
  year={2001},
  volume={69 10},
  pages={
          5981-90
        }
}
Two genes homologous to lpxL and lpxM from Escherichia coli and other gram-negative bacteria, which are involved in lipid A acyloxyacylation, were identified in Neisseria meningitidis strain H44/76 and insertionally inactivated. Analysis by tandem mass spectrometry showed that one of the resulting mutants, termed lpxL1, makes lipopolysaccharide (LPS) with penta- instead of hexa-acylated lipid A, in which the secondary lauroyl chain is specifically missing from the nonreducing end of the GlcN… CONTINUE READING

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