Modification of in vitro drug release rate from oily parenteral depots using a formulation approach.

@article{Fredholt2000ModificationOI,
  title={Modification of in vitro drug release rate from oily parenteral depots using a formulation approach.},
  author={Karin Fredholt and Dorthe Helena Larsen and Claus Larsen},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2000},
  volume={11 3},
  pages={231-7}
}
Rate constants for transfer of naproxen and lidocaine from different oils and oil mixtures to aqueous buffer, pH 6.00, were determined using the rotating dialysis cell. Significantly different first-order rate constants related to attainment of equilibrium, k(obs), were derived depending on the type of oil/oil mixtures used in the release experiments. For the drugs a linear correlation was found between logk(obs) and the logarithm of the partition coefficient P(app): logk(obs)=-0.68 logP(app)-0… CONTINUE READING