Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection.

@article{Harrison1988ModificationOI,
  title={Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection.},
  author={Christopher J. Harrison and L J Jenski and T Voychehovski and David I. Bernstein},
  journal={Antiviral research},
  year={1988},
  volume={10 4-5},
  pages={209-23}
}
R-837, a compound with no in vitro anti-HSV activity, was administered intravaginally to guinea pigs (5 mg/kg every 12 h) for five days beginning 12 h after genital HSV-2 inoculation. Drug treatment reduced vaginal viral replication (P less than 0.0001), completely protected against primary disease and reduced recurrent genital HSV disease (P less than 0.0001). Drug treatment also induced mild fever, weight loss, and decreased water intake. R-837 was a potent interferon inducer, which also… CONTINUE READING

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