Modification of human prekeratin during epidermal differentiation.

  title={Modification of human prekeratin during epidermal differentiation.},
  author={Paul Bowden and William James Cunliffe},
  journal={The Biochemical journal},
  volume={199 1},
The polypeptide-chain components of human epidermal prekeratin and keratin were analysed by high-resolution SDS (sodium dodecyl sulphate)/polyacrylamide-gradient-gel electrophoresis. Size heterogeneity existed amongst prekeratin components and at least ten polypeptides, in the molecular-weight range 46,000-70,000, were observed in 0.1 M-citric acid/sodium citrate buffer (pH 2.65) extracts of scale epidermis. Prekeratin from scalp pilosebaceous ducts was identical with that from the contiguous… CONTINUE READING