Modification of histidine biosynthesis pathway genes and the impact on production of l-histidine in Corynebacterium glutamicum

@article{Cheng2013ModificationOH,
  title={Modification of histidine biosynthesis pathway genes and the impact on production of l-histidine in Corynebacterium glutamicum},
  author={Yongsong Cheng and Yunjiao Zhou and Lei Yang and Chenglin Zhang and Qing-yang Xu and Xixian Xie and Ning Chen},
  journal={Biotechnology Letters},
  year={2013},
  volume={35},
  pages={735-741}
}
Histidine biosynthesis in Corynebacterium glutamicum is regulated not only by feedback inhibition by the first enzyme in the pathway, but also by repression control of the synthesis of the histidine enzymes. C. glutamicum histidine genes are located and transcribed in two unlinked loci, hisEG and hisDCB-orf1-orf2-hisHA-impA-hisFI. We constructed plasmid pK18hisDPtac to replace the native hisD promoter with the tac promoter, and overexpressed phosphoribosyl-ATP-pyrophosphohydrolase, encoded by… 

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