Modification of gating of an airway epithelial chloride channel by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB)

@article{Alton1992ModificationOG,
  title={Modification of gating of an airway epithelial chloride channel by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB)},
  author={Eric W. F. W. Alton and Alan R. Williams},
  journal={The Journal of Membrane Biology},
  year={1992},
  volume={128},
  pages={141-151}
}
5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) has been shown to produce a reduction in channel open probabilty i n a number of epithelial chloride channels. We have investigated its action on a calcium-dependent airway epithelial chloride channel, which shows voltage-dependent gating following incorporation into planar phospholipid bilayers. Since the channel demonstrates a distinct subconductance state at approximately one-third of the fully open level, both 50 and 20% threshold analysis… CONTINUE READING

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