Modification of enhancer chromatin: what, how, and why?

  title={Modification of enhancer chromatin: what, how, and why?},
  author={Eliezer Calo and Joanna Wysocka},
  journal={Molecular cell},
  volume={49 5},
Emergence of form and function during embryogenesis arises in large part through cell-type- and cell-state-specific variation in gene expression patterns, mediated by specialized cis-regulatory elements called enhancers. Recent large-scale epigenomic mapping revealed unexpected complexity and dynamics of enhancer utilization patterns, with 400,000 putative human enhancers annotated by the ENCODE project alone. These large-scale efforts were largely enabled through the understanding that… CONTINUE READING
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