Modification of elastin by pentosidine is associated with the calcification of aortic media in patients with end-stage renal disease.

@article{Sakata2003ModificationOE,
  title={Modification of elastin by pentosidine is associated with the calcification of aortic media in patients with end-stage renal disease.},
  author={Noriyuki Sakata and Akiko Noma and Yuji Yamamoto and Kouji Okamoto and Jing Meng and Shigeo Takebayashi and Ryoji Nagai and Seikoh Horiuchi},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2003},
  volume={18 8},
  pages={1601-9}
}
BACKGROUND Calcification of the media of arteries is common in patients with end-stage renal disease (ESRD) undergoing haemodialysis and is a major cause of arteriosclerosis. The aim of this study was to clarify the role of glycoxidative modification of elastin in the calcification of aortic media in this group of patients. METHODS Samples of tunica media were obtained from non-atherosclerotic areas of the aortas of cadavers of seven non-diabetic patients with ESRD (age 65.5 +/- 10.6 years… CONTINUE READING

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