Modification of early dimethylhydrazine carcinogenesis by colonic mucosal hyperplasia.

  title={Modification of early dimethylhydrazine carcinogenesis by colonic mucosal hyperplasia.},
  author={Stephen W. Barthold and Deborah S. Beck},
  journal={Cancer research},
  volume={40 12},
The interaction of colonic mucosal hyperplasia with early 1,2-dimethylhydrazine (DMH) carcinogenesis was studied in random-bred NIH Swiss mice utilizing hyperplasia-inducing Citrobacter freundii. Mice inoculated with this bacterium developed significantly more DMH focal atypia than did mice without hyperplasia following a single dose of DMH (20 mg/kg). Mice with hyperplasia also developed DMH focal atypia with diminished doses of DMH (10 and 5 mg/kg), while normal mice did not. The effect of C… CONTINUE READING

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