Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane).

@article{Chakrabarti2001ModificationOD,
  title={Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane).},
  author={K. Chakrabarti and J. Hopewell and D. Wilding and P. Plowman},
  journal={European journal of cancer},
  year={2001},
  volume={37 11},
  pages={
          1435-42
        }
}
The capacity of an oil, containing gamma-linolenic acid (GLA), to reduce the severity of doxorubicin-induced cardiotoxicity has been investigated in a rat model. Groups of 12-week-old, male, Sprague-Dawley rats were injected intravenously (i.v.) with single doses (3 mg/kg body weight) of doxorubicin (DOX). Daily for 1 week prior to DOX administration and for up to 20 weeks afterwards groups of rats received either an oil containing both GLA and linoleic acid (So-1100, Scotia Pharmaceuticals… Expand
Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats
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References

SHOWING 1-10 OF 35 REFERENCES
Reduction of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits.
A functional assessment of the relative cardiotoxicity of adriamycin and epirubicin in the rat.
Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids.
Time- and dose-related modifications in cardiac function in rats after single intravenous doses of epirubicin.
...
1
2
3
4
...