Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.
@article{Selvakumar2006ModificationOC, title={Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.}, author={Elangovan Selvakumar and Chidambaram Prahalathan and P. Varalakshmi and P. Kumarasamy and Revathy Saravanan}, journal={Mutation research}, year={2006}, volume={606 1-2}, pages={ 85-91 } }
The aim of the present study was to investigate the protective efficacy of alpha-lipoic acid (LA) on the cyclophosphamide (CP)-induced chromosomal aberrations (CA) and apoptosis in the bone marrow of rats. Male Wistar rats of 140+/-20 g were categorized into eight groups. Five groups were administered CP (40 mg/kg body weight, intraperitoneally) to induce toxicity; four of these groups received a single intraperitoneal injection of LA at a dose of either 100 or 200 mg/kg body weight, and either…
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