• Corpus ID: 34031610

Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.

  title={Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.},
  author={Elangovan Selvakumar and Chidambaram Prahalathan and P. Varalakshmi and P. Kumarasamy and Revathy Saravanan},
  journal={Mutation research},
  volume={606 1-2},
The aim of the present study was to investigate the protective efficacy of alpha-lipoic acid (LA) on the cyclophosphamide (CP)-induced chromosomal aberrations (CA) and apoptosis in the bone marrow of rats. Male Wistar rats of 140+/-20 g were categorized into eight groups. Five groups were administered CP (40 mg/kg body weight, intraperitoneally) to induce toxicity; four of these groups received a single intraperitoneal injection of LA at a dose of either 100 or 200 mg/kg body weight, and either… 

Effects of melatonin on DNA damage induced by cyclophosphamide in rats

Melatonin is able to protect bone marrow cells by completely blocking CP-induced chromosome aberrations, indicating that melatonin administration could be an alternative and effective treatment during chemotherapy.

Chemoprotective and chemosensitizing properties of selenium nanoparticle (Nano-Se) during adjuvant therapy with cyclophosphamide in tumor-bearing mice

Nano-Se exhibits significant antitumor and antioxidant effects in EAC-bearing mice, and the potential for Nano-Se to ameliorate the CP-evoked toxicity as well as to improve the chemotherapeutic effect could have beneficial implications for patients undergoing chemotherapy with CP.

Toxicogenomics: Genexpressionsanalysen zur Charakterisierung und Identifizierung genotoxischer Verbindungen

Die in vitro-Testsysteme der derzeitigen Standardbatterie fur die toxikologische Charakterisierung genotoxischer Verbindungen, insbesondere die Tests an Saugerzellen, sind hoch sensitiv, besitzen

Oxidative Stress and Gamma Radiation-induced Cancellous Bone Loss 1 with Musculoskeletal Disuse 2

Results showed that disuse and gamma irradiation, alone or combined, caused a similar degree of acute cancellous bone loss and showed that injection of α -lipoic acid, an anti-oxidant, mitigated the acute bone loss caused by irradiation.