• Corpus ID: 34031610

Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.

@article{Selvakumar2006ModificationOC,
  title={Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.},
  author={Elangovan Selvakumar and Chidambaram Prahalathan and P. Varalakshmi and P. Kumarasamy and Revathy Saravanan},
  journal={Mutation research},
  year={2006},
  volume={606 1-2},
  pages={
          85-91
        }
}
The aim of the present study was to investigate the protective efficacy of alpha-lipoic acid (LA) on the cyclophosphamide (CP)-induced chromosomal aberrations (CA) and apoptosis in the bone marrow of rats. Male Wistar rats of 140+/-20 g were categorized into eight groups. Five groups were administered CP (40 mg/kg body weight, intraperitoneally) to induce toxicity; four of these groups received a single intraperitoneal injection of LA at a dose of either 100 or 200 mg/kg body weight, and either… 

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