Modification of chemical toxicity by selenium deficiency.

  title={Modification of chemical toxicity by selenium deficiency.},
  author={Raymond F. Burk and Joanne M Lane},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={3 4},
Selenium deficiency causes a number of hepatic metabolic alterations in the rat which could lead to changes in chemical toxicity. It causes a decrease in glutathione peroxidase activity, an increase in glutathione S-transferase activity, and an increase in the rate of glutathione synthesis. The hepatotoxicities of three compounds which bind to glutathione S-transferase; iodipamide, acetaminophen, and aflatoxin B1, are decreased by selenium deficiency. The toxicity of redox cycling compounds is… CONTINUE READING


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